Biobanking 3.0! « Charlie Teo Foundation

Biobanking 3.0!

Researcher name: Charlie Teo Foundation
Institution: Charlie Teo Foundation, AUS
Grant name: More Data Grant
Grant amount: $340K
Grant years: 2019 →

Dr Charlie Teo has dedicated his time to collecting samples for over 10 years making this resource one of the largest and most varied to study brain cancer. Now in an Australian-first, the Charlie Teo Foundation Brain Tumour Bank will extract DNA from samples and analyse and map their genetic code making this data available for researchers to use. That data essentially creates a virtual copy of the sample, meaning a single sample can now be used in multiple brain cancer studies at the same time!

Charlie Teo Foundation Brain Tumour Bank will take precision medicine – the knowledge of an individual’s genetic code – to the next level. This will form the foundation for researchers to begin to understand how an individuals’ genetic code interacts and behaves with various factors that results in their brain cancer. Understanding this may lead to targeted treatments that will make a significant difference to an individual beating brain cancer.

Charlie Teo Foundation Brain Tumour Bank

Charlie Teo Foundation Brain Tumour Bank is a safe house for samples of human tissue, live cells, DNA and blood to be used for brain cancer research. It will help researchers understand what is unique and different about each individual’s brain cancer and contribute to expanding knowledge on diagnosis, prognosis and treatment.

The Brain Tumour Bank is unique because not only will it collect tissue and blood samples, as routinely collected by Australian brain biobanks, but will determine the precise sequence of every nitrogenous base pair that makes up the genetic code of the patients who have donated their samples. This provides a highly comprehensive, cost-effective, time-saving and invaluable resource for researchers to use to help advance our research of brain cancer.

Charlie Teo Foundation Brain Tumour Bank will also be unique in establishing a cell line repository of real-world brain tumours, which could be utilised in future to learn more about the behaviours of these tumours. Successful development of these cell lines will provide valuable and accurate models that will enable more refined analysis of the mechanisms that regulate individual patient response to treatment and allow the development of models for precision medicine.