Cold plasma discharge tube for glioblastoma treatment
The standard of care for newly diagnosed GBM is maximal surgical resection followed by concurrent radiation and chemotherapy then adjuvant chemotherapy (i.e., temozolomide (TMZ)), which has been shown to only improve median survival ranging from 12-22 months and a dismal five-year survival rate of less than 10%. To date, no effective method exists to eradicate malignant glioblastoma. Researching the literature on available cancer therapies led to the following conclusions: (a) there is a need for non-invasive cancer treatment therapies that selectively induce cancer cell death without harming normal cells; (b) current comparable treatments, including tumour-treating fields (TTFs), require long treatment times from 18-22 hours per day, consistent head shaving, and are reported to cause > 10% skin irritation and sleep disturbances. To overcome these drawbacks, this team proposes a new treatment approach based on its proprietary Plasma Discharge Tube (PDT) Technology that is designed for non-invasive treatment of glioblastoma (GBM) in combination with chemotherapy. Cold Atmospheric Plasma (CAP), utilized for the development of the PDT device, has consistently exhibited a positive anticancer activity as a stand-alone therapy that can provide genotoxic and phototoxic effects. An ongoing study at GWU suggests that electromagnetic waves formed by CAP can be coupled with cells and might lead to cancer cell sensitization. Unlike drugs, the effect of the PDT delivery system is not diffusion-dependent because the CAP jet can be positioned to treat specific regions in a tumour.